Dopamine release during sequential finger movements in health and Parkinson’s disease: a PET study
Identifieur interne : 001781 ( Main/Exploration ); précédent : 001780; suivant : 001782Dopamine release during sequential finger movements in health and Parkinson’s disease: a PET study
Auteurs : Ines K. Goerendt ; Cristina Messa ; Andrew D. Lawrence ; Paul M. Grasby ; Paola Piccini ; David J. BrooksSource :
- Brain [ 0006-8950 ] ; 2003-02.
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Abstract
Parkinson’s disease is associated with slowness, especially of sequential movements, and is characterized pathologically by degeneration of dopaminergic neurons, particularly targeting nigrostriatal projections. In turn, nigrostriatal dopamine has been suggested to be critical for the execution of sequential movements. The objective of this study was to investigate in vivo, with [11C]raclopride, PET changes in regional brain levels of dopamine in healthy volunteers and Parkinson’s disease patients during the execution of paced, stereotyped sequential finger movements. Striatal [11C]raclopride binding reflects dopamine D2 receptor availability and is influenced by synaptic levels of endogenous dopamine. During execution of a pre‐learned sequence of finger movements, a significant reduction in binding potential (BP) of [11C]raclopride was seen in both caudate and putamen in healthy volunteers compared with a resting baseline, consistent with release of endogenous dopamine. Parkinson’s disease patients also showed attenuated [11C]raclopride BP reductions during the same motor paradigm in striatal areas less affected by the disease process. These findings confirm that striatal dopamine release is a component of movement sequencing and show that dopamine release can be detected in early Parkinson’s disease during a behavioural manipulation.
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DOI: 10.1093/brain/awg035
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Grasby</name></author><author><name sortKey="Piccini, Paola" sort="Piccini, Paola" uniqKey="Piccini P" first="Paola" last="Piccini">Paola Piccini</name></author><author><name sortKey="Brooks, David J" sort="Brooks, David J" uniqKey="Brooks D" first="David J." last="Brooks">David J. 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Brooks</name><affiliation><wicri:noCountry code="syntax">???</wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j">Brain</title><title level="j" type="abbrev">Brain</title><idno type="ISSN">0006-8950</idno><idno type="eISSN">1460-2156</idno><imprint><publisher>Oxford University Press</publisher><date type="published" when="2003-02">2003-02</date><biblScope unit="volume">126</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="312">312</biblScope><biblScope unit="page" to="325">325</biblScope></imprint><idno type="ISSN">0006-8950</idno></series><idno type="istex">843AD076B8B7851E2994DD8E23B6FBBAF8338EDF</idno><idno type="DOI">10.1093/brain/awg035</idno><idno type="local">awg035</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0006-8950</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Abbreviations: BP = binding potential; DA = dopamine; RAC = [11C]raclopride; ROI = region of interest; SED = standard error of the difference of the means; SMA = supplementary motor area</term><term>Keywords: Parkinson’s disease; dopamine; [11C]raclopride PET; sequential movement; fMRI</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Parkinson’s disease is associated with slowness, especially of sequential movements, and is characterized pathologically by degeneration of dopaminergic neurons, particularly targeting nigrostriatal projections. In turn, nigrostriatal dopamine has been suggested to be critical for the execution of sequential movements. The objective of this study was to investigate in vivo, with [11C]raclopride, PET changes in regional brain levels of dopamine in healthy volunteers and Parkinson’s disease patients during the execution of paced, stereotyped sequential finger movements. Striatal [11C]raclopride binding reflects dopamine D2 receptor availability and is influenced by synaptic levels of endogenous dopamine. During execution of a pre‐learned sequence of finger movements, a significant reduction in binding potential (BP) of [11C]raclopride was seen in both caudate and putamen in healthy volunteers compared with a resting baseline, consistent with release of endogenous dopamine. Parkinson’s disease patients also showed attenuated [11C]raclopride BP reductions during the same motor paradigm in striatal areas less affected by the disease process. 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